Antioxidant enzymes of the rat liver, brain, heart and erythrocytes in ammonia intoxication

Injection of large amounts of ammonium salts leads to rapid death of animals. However, the molecular mechanisms involved in ammonia toxicity remain to be clarified. We have tested the effect of toxic dose of ammonium acetate on the activities of antioxidant enzymes in rat liver, brain, heart and ery...

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Bibliographic Details
Published in:	Biomeditsinskaia khimiia Vol. 51; no. 2; p. 185
Main Authors:	Venediktova, N I, Lopata, O V, Pogosian, A S, Kosenko, E A, Kaminskiĭ, Iu G
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-03-2005
Subjects:	Acetates - toxicity Animals Brain - drug effects Brain - enzymology Erythrocytes - drug effects Erythrocytes - enzymology Liver - drug effects Liver - enzymology Male Mitochondria, Heart - drug effects Mitochondria, Heart - enzymology Mitochondria, Liver - drug effects Mitochondria, Liver - enzymology Myocardium - enzymology Oxidoreductases - metabolism Rats Rats, Wistar
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Summary:	Injection of large amounts of ammonium salts leads to rapid death of animals. However, the molecular mechanisms involved in ammonia toxicity remain to be clarified. We have tested the effect of toxic dose of ammonium acetate on the activities of antioxidant enzymes in rat liver, brain, heart and erythrocytes. Acute ammonia intoxication resulted in rapid (within 11 min) decrease in superoxide dismutase, catalase and glutathione peroxidase activities in liver and brain mitochondria and cytosol and in erythrocytes, but in increase of these enzyme activities in heart. Diminished activities of the antioxidant enzymes in liver, brain and erythrocytes suggest that the systemic oxidative stress takes place, whereas their elevated activities in heart can be the adaptive reaction to oxidative stress in hyperammoniemia.
ISSN:	2310-6972