Status epilepticus--the new mechanisms and lines of inhibition (the lithium-pilocarpine model)

• Published in: Uspekhi fiziologicheskikh nauk Vol. 36; no. 1; p. 68
• Main Authors: Chepurnov, S A, Chepurnova, N E, Redkozubova, O M, Saakian, S A
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 01-01-2005
• Subjects: Animals; Anticonvulsants - administration & dosage; Anticonvulsants - therapeutic use; Brain - physiopathology; Disease Models, Animal; Humans; Injections, Intraperitoneal; Limbic System - metabolism; Lithium; Pilocarpine; Potassium Channels, Voltage-Gated - physiology; Rats; Receptors, Cholinergic - metabolism; Receptors, Glutamate; Receptors, Muscarinic - metabolism; Status Epilepticus - chemically induced; Status Epilepticus - drug therapy; Thyrotropin-Releasing Hormone - administration & dosage; Thyrotropin-Releasing Hormone - therapeutic use
• ISSN: 0301-1798

This review focuses on the modeling of status epilepticus in animal brain and modern data on the mechanisms of epileptical seizures initiation using the pilocarpine binding with the muscarinic cholinoreceptors (litium pilocarpine model). The character of epileptics seizures in developing brain and adult brain of rats were investigated. The lines of modulation and inhibition epileptics statues by sacricine and intranasal application of neuropeptide thyroliberin in ultra-low doses are demonstrated. The role of the short-term changes (signal regulated kinase signaling cascade, Kv 4.2 potassium channels, hippocampal and cortical spike-wave discharges) and the long-term changes (loss of selective type of interneurons, excitatory circuits by mossy fiber sprouting) that promotion the epileptic state and recurrent seizures in limbic structure are discussed.