Changes in immunogenesis organs after thyroidectomy and hormonal correction in an experiment

Regulating effect of thyroid hormones on functions of organs of the immune system has been demonstrated in the experiment. Deficiency of thyroid hormones affects thymulin synthesis and morphofunctional status of immunogenesis organs. Combination of thymostimulin and thyroxin in the thyroidectomized...

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Bibliographic Details
Published in:	Arkhiv patologii Vol. 64; no. 5; p. 45
Main Authors:	Bobro, L I, Grinevich, Iu A, Bendiug, G D
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-09-2002
Subjects:	Adjuvants, Immunologic - therapeutic use Animals Anticoagulants - pharmacology Drug Therapy, Combination Heparin - pharmacology Mast Cells - metabolism Rats Rats, Inbred Strains Spleen - cytology Spleen - immunology Spleen - metabolism Thymus Extracts - therapeutic use Thymus Gland - cytology Thymus Gland - immunology Thymus Gland - metabolism Thyroidectomy Thyroxine - therapeutic use
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Summary:	Regulating effect of thyroid hormones on functions of organs of the immune system has been demonstrated in the experiment. Deficiency of thyroid hormones affects thymulin synthesis and morphofunctional status of immunogenesis organs. Combination of thymostimulin and thyroxin in the thyroidectomized animals, as compared to their separate use, is pathogenetically the most adequate correcting therapy aiming normalization of structural and functional disorders in the thymus and spleen. Prolonged reaction of tissual basophils saturated with heparin, indicated hormonal activation of blood anticoagulative system, and complex of the above hormones can be used for prevention of thromboembolic complications.
ISSN:	0004-1955