Bacterial IgA1-protease: production, properties and prospects for use

Some pathogenic bacteria have been demonstrated to secrete specific IgA1-proteases, the enzymes cleaving the molecules of the first subclass of human immunoglobulin (IgA1) in the single point from the hinge with the formation of Fab- and Fc-fragments. Cleavage generally deprives immunoglobulins havi...

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Bibliographic Details
Published in:	Vestnik Rossiĭskoĭ akademii medits︠i︡nskih nauk no. 12; p. 39
Main Authors:	Surovtsev, V I, Fedorov, T V, Gusev, V V
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 2001
Subjects:	Animals Bacterial Vaccines - administration & dosage Bacterial Vaccines - immunology Gram-Negative Bacteria - enzymology Gram-Negative Bacteria - pathogenicity Humans Hydrolysis Immunoglobulin A, Secretory - chemistry Immunoglobulin A, Secretory - metabolism Meningitis, Bacterial - prevention & control Primates Serine Endopeptidases - genetics Serine Endopeptidases - metabolism Virulence
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Summary:	Some pathogenic bacteria have been demonstrated to secrete specific IgA1-proteases, the enzymes cleaving the molecules of the first subclass of human immunoglobulin (IgA1) in the single point from the hinge with the formation of Fab- and Fc-fragments. Cleavage generally deprives immunoglobulins having defense properties and the enzymes are considered as pathogenic factors. How to determine the activity, purification, and the promises of use of IgA-proteases is described. Whether inactivated meningococcal IgA1-protease as a vaccine against any of the five (A, B, C, Y, W135) serotypes of pathogenic meningococci is discussed.
ISSN:	0869-6047