Effect of a postsynaptic alpha2-adrenoreceptor antagonist beditin on the rat resistance to seizure and Ca(+)-level in the brain tissue

In rats with a hemodynamic disorder caused by acute myocardial ischemia, preliminary administration of beditin in a dose of 25 mg/kg fully prevents a manifold increase in the level of 45Ca2+ in the cytosol of brain cells and leads to enhanced trapping and accumulation of labeled calcium in endoplasm...

Full description

Saved in:

Bibliographic Details
Published in:	Ėksperimentalʹnaâ i kliničeskaâ farmacologiâ Vol. 67; no. 1; p. 11
Main Authors:	Shirinian, E A, Arutiunian, S A, Petrosian, A A, Gevorkian, G A, Markarian, E A, Vartanian, S O, Medvedev, O S, Garibdzhanian, B T
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-01-2004
Subjects:	Adrenergic alpha-2 Receptor Antagonists Animals Anticonvulsants - therapeutic use Brain - metabolism Calcium - metabolism Calcium Channel Blockers - therapeutic use Dioxanes - therapeutic use Endoplasmic Reticulum - metabolism Mice Rats Seizures - drug therapy Seizures - etiology Seizures - metabolism Species Specificity Thiazoles - therapeutic use
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	In rats with a hemodynamic disorder caused by acute myocardial ischemia, preliminary administration of beditin in a dose of 25 mg/kg fully prevents a manifold increase in the level of 45Ca2+ in the cytosol of brain cells and leads to enhanced trapping and accumulation of labeled calcium in endoplasmic reticulum. With respect to calcium binding in endoplasmic reticulum, the action of beditin substantially differs from that of verapamil.
ISSN:	0869-2092