The specific features of lipid metabolism and changes in the plasma activity of transaminases in patients with sepsis

• Published in: Anesteziologiia i reanimatologiia no. 6; p. 13
• Main Authors: Shcherbakova, L N, Iakovleva, I I, Molchanova, L V
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 01-11-2004
• Subjects: Adult; Cholesterol, VLDL - blood; Cholesterol, VLDL - metabolism; Female; gamma-Glutamyltransferase - blood; Hemofiltration; Humans; Male; Middle Aged; Prognosis; Sepsis - metabolism; Sepsis - mortality; Sepsis - therapy; Shock, Septic - metabolism; Shock, Septic - mortality; Shock, Septic - therapy; Treatment Outcome; Triglycerides - blood; Triglycerides - metabolism
• ISSN: 0201-7563

A parallel study of changes in the activity of transaminases and the parameters of lipid metabolism was conducted in patients with sepsis or septic shock, receiving renal replacement therapy. The multiple baseline increase in the activity of gamma-glutamyltranspeptidase was observed in about 50% of the patients and the elevated level of triglycerides and very low density-lipoprotein cholesterol in all the examinees. In case of the baseline multiple increased activity of gamma-glutamyltranspeptidase as compared with the normal physiological values, the probability of a good clinical outcome was some 67%, in the survivors, the activity of the enzyme significantly increasing during therapy. In the absence of the baseline multiple increased activity of gamma-glutamyltranspeptidase, there was a good clinical outcome provided that there were positive changes in triglycerides and very low-density lipoprotein cholesterol during therapy and its probability was about 33%. It is concluded that the activity of gamma-glutamyltranspeptidase and the concentration of triglycerides and very low-density lipoprotein cholesterol may be used to evaluate the efficiency of treatment and as predictors of the outcome of treatment in patients with sepsis and septic shock.