Cellular aspects of hypertrophic cardiomyopathy pathogenesis: the role of cardiomyocyte polyploidy and activation of the proliferating cell nuclear antigen in the myocardium

Mechanisms of hypertrophy development in hypertrophic obstructive cardiomyopathy (HOCM) have not been enough investigated. In our study, there have been examined patients with severe HOCM at different ages, including children, and patients with essential arterial hypertension (EAH). There was found,...

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Bibliographic Details
Published in:	T͡S︡itologii͡a Vol. 49; no. 10; p. 817
Main Authors:	Shliakhto, E V, Bokeriia, L A, Rybakova, M G, Semernin, E N, Selivanova, G V, Vlasova, T D, Borisov, K V, Parfenov, V N, Gudkova, A Ia
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 2007
Subjects:	Adolescent Adult Aged Aged, 80 and over Aging - genetics Aging - metabolism Aging - pathology Cardiomyopathy, Hypertrophic - etiology Cardiomyopathy, Hypertrophic - genetics Cardiomyopathy, Hypertrophic - pathology Cell Nucleus - genetics Cell Nucleus - metabolism Child Child, Preschool Humans Middle Aged Myocardium - metabolism Myocardium - pathology Myocytes, Cardiac - metabolism Myocytes, Cardiac - pathology Polyploidy Proliferating Cell Nuclear Antigen - metabolism
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Summary:	Mechanisms of hypertrophy development in hypertrophic obstructive cardiomyopathy (HOCM) have not been enough investigated. In our study, there have been examined patients with severe HOCM at different ages, including children, and patients with essential arterial hypertension (EAH). There was found, that HOCM in children compared to adults was characterized by considerable interventricular septum (IVS) hypertrophy and it was accompanied by the acceleration of cardiomyocyte polyploidy. The average ploidy level of cardiomyocytes in children with HOCM was higher than analogous indices in adults. The average ploidy level of nuclei, the part of PCNA-positive nuclei and polyploidic nuclei of cardiomyocytes in aduls with HOCM were authentically higher than in patients with EAH. Activation of the nuclear antigen in stromal cells was detected only in patients with HOCM. Our findings provide evidence of an important role of cardiomyocyte polyploidy and activation of the proliferating cell nuclear antigen in development of the myocardial hypertrophy in patients with HOCM.
ISSN:	0041-3771