The action of timoptin peptides on the hemostatic system

Repeated introduction of thymus polypeptide drug thymoptine (8 times every 24 hours, 1 microgram/kg) led to the increase in total and non-enzymatic fibrinolytic activity of blood plasma and the decrease in fibrinogen concentration. Thymoptine could lyse non-stabilized fibrin and cause depolymerizati...

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Bibliographic Details
Published in:	Izvestiia Akademii nauk SSSR. Seriia biologicheskaia no. 3; p. 377
Main Authors:	Liapina, L A, Pastorova, V E, Kudriashov, B A, Zazhireĭ, V D, Sokolova, E A, Livshits, V A, Ashmarin, I P
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-05-1990
Subjects:	Animals Blood Coagulation Tests Dose-Response Relationship, Drug Fibrinolysis - drug effects Hemostasis - drug effects In Vitro Techniques Male Peptides - pharmacology Rats Thymosin - analogs & derivatives Thymus Extracts - pharmacology Thymus Gland
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Summary:	Repeated introduction of thymus polypeptide drug thymoptine (8 times every 24 hours, 1 microgram/kg) led to the increase in total and non-enzymatic fibrinolytic activity of blood plasma and the decrease in fibrinogen concentration. Thymoptine could lyse non-stabilized fibrin and cause depolymerization of aggregates of fibrin monomer in virto. Highest depolymerization activity was observed at thymoptine concentration of 10 micrograms/ml.
ISSN:	0002-3329