Amino acid substitutions in the beta-subunit of RNA-polymerase from E. coli compensating for mutation-induced damage of the rho termination factors

Ts-phenotype of the E. coli rho-factor mutant rho 15 is suppressed by two rifampicin-resistance mutations, rhoB1019 resulting in a single amino acid substitution Val146---Phe and rhoB268 resulting in a single substitution Gln513---Leu in beta-subunit of the E. coli RNA polymerase. Rifampicin-resista...

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Bibliographic Details
Published in:	Bioorganicheskaia khimiia Vol. 14; no. 7; p. 963
Main Authors:	Ogryz'ko, E P, Nikiforov, V G, Borodin, A M, Danilkovich, A V, Monastyrskaia, G S
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-07-1988
Subjects:	DNA-Directed RNA Polymerases - genetics Escherichia coli - enzymology Escherichia coli - genetics Mutation Peptide Termination Factors - genetics Phenotype Rho Factor - genetics Rifampin - pharmacology Transcription Factors - genetics
Online Access:	Get more information
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Summary:	Ts-phenotype of the E. coli rho-factor mutant rho 15 is suppressed by two rifampicin-resistance mutations, rhoB1019 resulting in a single amino acid substitution Val146---Phe and rhoB268 resulting in a single substitution Gln513---Leu in beta-subunit of the E. coli RNA polymerase. Rifampicin-resistance mutations rhoB255 (Asp516---Val), rhoB1016 (Asp516---Asn), rhoB1001 (His526---Tyr), rhoB1004 (Ser531---Phe), rhoB1005 (Pro564---Leu), and streptolydigin-resistance' mutation rhoB1018 (double substitution Gly544---Asp and Phe545---Ser) do not suppress the rho15 mutation.
ISSN:	0132-3423