Role of phospholipids in changes in lysosomal membrane stability in conditions of chronic alcoholic intoxication

Pronounced destabilization of liver lysosomal membranes has been revealed in rats in conditions of 30-day-long alcohol intoxication. Noticeable fractional changes in phospholipid composition of lysosomal membranes have been found. Significant increase in lysophosphatidylethanolamine and lysophosphat...

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Bibliographic Details
Published in:	Biulleten' eksperimental'noi biologii i meditsiny Vol. 100; no. 11; p. 553
Main Authors:	Tadevosian, Iu V, Karagezian, K G, Gevorkian, G A, Batikian, T B
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-11-1985
Subjects:	Alcoholism - pathology Animals Intracellular Membranes - pathology Liver - pathology Lysosomes - pathology Male Phospholipids - physiology Rats
Online Access:	Get more information
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Summary:	Pronounced destabilization of liver lysosomal membranes has been revealed in rats in conditions of 30-day-long alcohol intoxication. Noticeable fractional changes in phospholipid composition of lysosomal membranes have been found. Significant increase in lysophosphatidylethanolamine and lysophosphatidylcholine levels have been observed. Type A2 phospholipase activity was found in lysosomal fractions, with the enzyme activity Ca2+-dependent, optimal at pH 8 and increasing many-fold following alcohol intoxication. The changes in lysosomal membrane phospholipids appear to be related to phospholipase A2 activation.
ISSN:	0365-9615