Potentiation of the selective antitumoral effect of cyclophosphamide and 5-fluorouracil by its combination with amphotericin B and diacarb

• Published in: Voprosy onkologij Vol. 32; no. 7; p. 61
• Main Authors: Iaremenko, K V, Bychkov, I A, Pashinskiĭ, V G
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 1986
• Subjects: Acetazolamide - administration & dosage; Acetazolamide - therapeutic use; Amphotericin B - administration & dosage; Amphotericin B - therapeutic use; Animals; Antineoplastic Combined Chemotherapy Protocols - administration & dosage; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Antineoplastic Combined Chemotherapy Protocols - toxicity; Cyclophosphamide - administration & dosage; Cyclophosphamide - toxicity; Drug Synergism; Drug Therapy, Combination; Female; Fluorouracil - administration & dosage; Fluorouracil - toxicity; Male; Mice; Mice, Inbred Strains; Neoplasms, Experimental - drug therapy; Rats; Rats, Inbred Strains
• ISSN: 0507-3758

The paper deals with the results of experiments which were carried out on 10 tumor models and used approximately 1,000 animals (mice and rats of different strains). Such cytostatic drugs as cyclophosphamide (alkylating agent) and 5-fluorouracil (antimetabolite) showed a significantly enhanced antitumor and metastation--preventing effect when used in combination with polyene antibiotic amphotericin B and a diuretic drug--diacarb. This was matched by a pronounced amelioration of toxic side effects and an increase in the animals' lifespan. The said method of treatment should be integrated with oncological practice.