Long-term selective IgG immuno-adsorption improves Rasmussen's encephalitis

We report that long-term selective immunoglobulin G immunoadsorption by protein A (PAI) improved seizure frequency and neuropsychological deficits in a 16-year-old patient with severe treatment-resistant Rasmussen's encephalitis (RE). Clinical improvement correlated with reduction of antiglutam...

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Bibliographic Details
Published in:	Neurology Vol. 51; no. 1; pp. 302 - 305
Main Authors:	Antozzi, C, Granata, T, Aurisano, N, Zardini, G, Confalonieri, P, Airaghi, G, Mantegazza, R, Spreafico, R
Format:	Journal Article
Language:	English
Published:	United States 01-07-1998
Subjects:	Adolescent Autoantibodies - isolation & purification Encephalitis - immunology Encephalitis - therapy Epilepsia Partialis Continua - immunology Epilepsia Partialis Continua - therapy Female Humans Immunoglobulin G - isolation & purification Immunosorbents Language Neuropsychological Tests Receptors, Metabotropic Glutamate - immunology Staphylococcal Protein A - immunology
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Summary:	We report that long-term selective immunoglobulin G immunoadsorption by protein A (PAI) improved seizure frequency and neuropsychological deficits in a 16-year-old patient with severe treatment-resistant Rasmussen's encephalitis (RE). Clinical improvement correlated with reduction of antiglutamate receptor 3 antibodies. The efficacy of PAI in our patient supports the autoimmune hypothesis of RE and suggests its application to avoid, or at least delay, functional hemispherectomy in selected cases.
Bibliography:	ObjectType-Case Study-2 SourceType-Scholarly Journals-1 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3
ISSN:	0028-3878