Blood levels and therapeutic effectiveness of piroxicam as affected by the time of administration

The nonsteroidal antirheumatic preparation hydroxy-2-methyl-N-(2-pyridyl)-2H-1.2-benzothiazine-3-carboxamide 1,1-dioxide (piroxicam, Feldene) from the oxicam group is administered as a single dose of 20 mg/d. The question hence arose as to whether the therapeutic efficacy and the blood level curve (...

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Bibliographic Details
Published in:	Arzneimittel-Forschung Vol. 35; no. 9; p. 1477
Main Authors:	Kullich, W, Wottawa, A, Klein, G
Format:	Journal Article
Language:	German
Published:	Germany 1985
Subjects:	Anti-Inflammatory Agents - administration & dosage Anti-Inflammatory Agents - blood Anti-Inflammatory Agents - therapeutic use Arthritis - drug therapy Humans Piroxicam Thiazines - administration & dosage Thiazines - blood Thiazines - therapeutic use Time Factors
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Summary:	The nonsteroidal antirheumatic preparation hydroxy-2-methyl-N-(2-pyridyl)-2H-1.2-benzothiazine-3-carboxamide 1,1-dioxide (piroxicam, Feldene) from the oxicam group is administered as a single dose of 20 mg/d. The question hence arose as to whether the therapeutic efficacy and the blood level curve (steady state) depend on the time of application. The investigation was carried out in 30 patients with arthroses of peripheral joints receiving the daily dose of piroxicam in the morning, at noon or in the evening. The results showed that irrespective of the time of administration the single dose of 20 mg/d led to a steady-state plasma level with the concentration required for efficacy. The result of therapy attained clinically also proved to be independent of the time of administration.
ISSN:	0004-4172