An increase in the rate of proteolysis in vitro after treatment with oxidized glutathione

The effect of the formation of mixed disulphides--protein-glutathione--on the proteolysis rate was studied using soluble fractions of proteins from different rat tissues as substrates. It was shown that the binding of oxidized glutathione to proteins increases the proteolysis rate under the effect o...

Full description

Saved in:

Bibliographic Details
Published in:	Ukrainskij biohimičeskij žurnal Vol. 59; no. 5; p. 24
Main Authors:	Agadzhanian, A G, Arzumanian, A M, Arutiunian, A A, Kalachian, A S, Akopian, T N
Format:	Journal Article
Language:	Russian
Published:	Ukraine 01-09-1987
Subjects:	Animals Disulfides - metabolism Glutathione - metabolism Glutathione - pharmacology Hydrolysis Oxidation-Reduction Proteins - metabolism Rats Rats, Inbred Strains Sulfhydryl Compounds - metabolism
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	The effect of the formation of mixed disulphides--protein-glutathione--on the proteolysis rate was studied using soluble fractions of proteins from different rat tissues as substrates. It was shown that the binding of oxidized glutathione to proteins increases the proteolysis rate under the effect of trypsin and chymotrypsin. When the concentration of oxidized glutathione is 5.10(-4) M a 1.2-1.4-fold increase in the proteolysis rate is registered and when the concentration is 5.10(-3) M a 1.4-1.8 fold increase is observed.
ISSN:	0201-8470