Late results of the treatment of the chronic progressive form of multiple sclerosis by intensive immunosuppression

A group of 16 patients with secondary chronic progression of multiple sclerosis treated by short-lasting intensive immunosuppression (cyclophosphamide with ACTH) by the programme of Hausser et al (4) was compared with a clinically similar group of 16 patients treated exclusively with intramuscular A...

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Bibliographic Details
Published in:	Neurologia i neurochirurgia polska Vol. 23; no. 3; p. 188
Main Authors:	Wender, M, Tokarz-Kupczyk, E, Mularek, O
Format:	Journal Article
Language:	Polish
Published:	Poland 01-05-1989
Subjects:	Adrenocorticotropic Hormone - administration & dosage Adult Chronic Disease Clinical Trials as Topic Cyclophosphamide - administration & dosage Drug Therapy, Combination Female Hormones - administration & dosage Humans Immunosuppressive Agents Male Middle Aged Multiple Sclerosis - drug therapy Multiple Sclerosis - immunology Random Allocation Remission Induction Time Factors
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Summary:	A group of 16 patients with secondary chronic progression of multiple sclerosis treated by short-lasting intensive immunosuppression (cyclophosphamide with ACTH) by the programme of Hausser et al (4) was compared with a clinically similar group of 16 patients treated exclusively with intramuscular ACTH. During 2 years of observation of the patients it was observed that short-lasting intensive immunosuppression induced with simultaneous administration of cyclophosphamide and ACTH had no beneficial effect on the slowly progressing form of multiple sclerosis. The observation leads to the conclusion that cyclophosphamide therapy should not be used in view of absence of favourable effect on the course of multiple sclerosis and the risk of increased frequency of malignant neoplasms which cannot be ruled out in this method.
ISSN:	0028-3843