The immunological cellular phenotype and the prognosis in neuroblastoma in children

Ganglioside profile was evaluated in 19 samples of tumor tissue obtained from 13 surgical patients with various morphological patterns of neuroblastoma. In six of those cases, two samples from each proving most different in terms of cell maturity were selected for examination. The relative content o...

Full description

Saved in:

Bibliographic Details
Published in:	Voprosy onkologij Vol. 36; no. 6; p. 693
Main Authors:	Novikov, A M, Blinov, V M, Bukhny, A F, Bassalyk, L S
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 1990
Subjects:	Biomarkers, Tumor - analysis Child Chromatography, Thin Layer Diagnosis, Differential Ganglioneuroma - analysis Ganglioneuroma - diagnosis Ganglioneuroma - immunology Ganglioneuroma - mortality Gangliosides - analysis Humans Neuroblastoma - analysis Neuroblastoma - diagnosis Neuroblastoma - immunology Neuroblastoma - mortality Phenotype Prognosis
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Ganglioside profile was evaluated in 19 samples of tumor tissue obtained from 13 surgical patients with various morphological patterns of neuroblastoma. In six of those cases, two samples from each proving most different in terms of cell maturity were selected for examination. The relative content of GD2 gangliosides was 27.0-37.6% in sympathoblastoma and as low as 5.1-14.8% in ganglioneuroblastoma. Ganglioneuroblastomas showed fairly high levels of GM1 and GD1a gangliosides which were almost completely absent in sympathoblastomas. Ganglioside profile variations seen within each tumor type were incomparable with differences in profile established between morphological patterns of neuroblastoma studied.
ISSN:	0507-3758