Effect of gamma-aminobutyric acid and gamma-hydroxybutyric acid on the rate of 14C-leucine incorporation into proteins of the gastric mucosa and hypothalamus

In experimental peptic ulcer the rate of labeled 14C-leucine inclusion in gastric mucosa proteins was decreased. Gamma-aminobutyric acid (GABA) and gamma-oxybutyric acid (GOBA) potentiated the inclusion of amino acids in gastric tissue and hypothalamus proteins, promoted the increased intensity of t...

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Bibliographic Details
Published in:	Biulleten' eksperimental'noi biologii i meditsiny Vol. 90; no. 9; p. 299
Main Authors:	Mirzoian, S A, Tatevosian, A T, Gevorkian, G A
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-09-1980
Subjects:	Animals Anti-Ulcer Agents gamma-Aminobutyric Acid - pharmacology gamma-Aminobutyric Acid - therapeutic use Gastric Mucosa - metabolism Hydroxybutyrates - pharmacology Hydroxybutyrates - therapeutic use Hypothalamus - metabolism Leucine - metabolism Nerve Tissue Proteins - biosynthesis Protein Biosynthesis Rats Stomach Ulcer - drug therapy Stomach Ulcer - metabolism
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Summary:	In experimental peptic ulcer the rate of labeled 14C-leucine inclusion in gastric mucosa proteins was decreased. Gamma-aminobutyric acid (GABA) and gamma-oxybutyric acid (GOBA) potentiated the inclusion of amino acids in gastric tissue and hypothalamus proteins, promoted the increased intensity of the trophic processes and exhibited an antiulcerous effect. Studies on 14C-GABA distribution in different organs of rats showed that the largest amount of the acid was detected in the liver and stomach, with a comparatively less amount being found in the hypothalamus.
ISSN:	0365-9615