Effect of cycloheximide on transcription in eukaryotic cells

Effect of cycloheximide on transcription in eukaryotic cells

The effects of the translation inhibitor cycloheximide on transcription in Rauscher virus transformed mouse erythroblasts and in barley rootlets were studied. In transformed erythroblasts, the globin gene transcription appeared to be blocked. Consecutive treatment of cells with sublethal doses of cy...

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Bibliographic Details
Published in:Biokhimiia (Moscow, Russia) Vol. 53; no. 4; p. 694
Main Authors: Peresleni, T Iu, Mavletova, D A, Dvorkin, G A
Format: Journal Article
Language:Russian
Published: Russia (Federation) 01-04-1988
Subjects:
Animals
Cell Line, Transformed
Cycloheximide - pharmacology
Erythrocytes - metabolism
Eukaryotic Cells
Hordeum
Mice
Transcription, Genetic - drug effects
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Summary:The effects of the translation inhibitor cycloheximide on transcription in Rauscher virus transformed mouse erythroblasts and in barley rootlets were studied. In transformed erythroblasts, the globin gene transcription appeared to be blocked. Consecutive treatment of cells with sublethal doses of cycloheximide (7 micrograms/ml) and actinomycin D resulted in the induction of synthesis of the protein fraction corresponding to beta-globin chains. An exposure of barley rootlets to cycloheximide caused changes in total RNA synthesis.
ISSN:0320-9725