The characteristics of the correlation of the functional activity, blood supply and structural organization in the sensory-deprived cerebral cortex in rats

• Published in: Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova Vol. 78; no. 11; p. 87
• Main Authors: Moskalenko, Iu E, Zhuravin, I A, Riasina, T V, Zaiats, N D, Kilibaeva, G S, Semernia, V N
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 01-11-1992
• Subjects: Animals; Animals, Newborn; Electric Stimulation - methods; Electroencephalography; Electrophysiology; Female; Male; Rats; Rats, Wistar; Sensory Deprivation - physiology; Somatosensory Cortex - blood supply; Somatosensory Cortex - physiology; Vibrissae - physiology
• ISSN: 0015-329X

The feature of correlation between functional activity of the brain tissue and structural-functional characteristics of the vascular system after sensory deprivation by the removal of whiskers in newborn animals were studied in nembutal-anaesthetized rats in comparison to the animals under d-tubocurarine with local anesthesia. It has been shown that there are major changes of EP parameters and ECoG in the sensory-deprived brain area and diminution of brain cortex thickness. Changes in the vascular system are mainly structural, what are revealed as disorganization in angioarchitecture of radial arteries. At the same time, differences in the blood circulation intensity are found in d-tubocurarine animals only. The largest volume of the local blood circulation is observed in intact hemisphere of sensory-deprived animal. Thus, it can be concluded that sensory-deprived model is the alternative to the ischemia model. This model can be used in studies of physiology of brain blood circulation, and the "structure-function" correlation, in particular.