Blood levels of 6-keto-prostaglandin F1alpha, thromboxane and prostaglandin F2alpha in patients with bronchial asthma

Blood levels of 6-keto-prostaglandin F1alpha, thromboxane and prostaglandin F2alpha in patients with bronchial asthma

The study revealed the relation of bronchial asthma (bacterial variant) clinical pattern to plasma levels of PGF2 alpha, 6-keto-PGF1 alpha and TxB2. In remission of the disease the above indices are lower. Severe asthma remission is characterized by higher levels of 6-keto-PGF1 alpha and TxB2 than m...

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Bibliographic Details
Published in:Klinicheskaia meditsina Vol. 71; no. 5; p. 24
Main Authors: Grigorian, L G, Chervinskaia, T A
Format: Journal Article
Language:Russian
Published: Russia (Federation) 1993
Subjects:
6-Ketoprostaglandin F1 alpha - blood
Adolescent
Adult
Asthma - blood
Asthma - etiology
Asthma - therapy
Dinoprost - blood
Female
Humans
Male
Middle Aged
Remission Induction
Severity of Illness Index
Thromboxane A2 - blood
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Summary:The study revealed the relation of bronchial asthma (bacterial variant) clinical pattern to plasma levels of PGF2 alpha, 6-keto-PGF1 alpha and TxB2. In remission of the disease the above indices are lower. Severe asthma remission is characterized by higher levels of 6-keto-PGF1 alpha and TxB2 than moderate asthma one, demonstrates a tendency to growing PGF2 alpha levels. A rise in PGF2 alpha and TxB2 in manifest asthma points to their participation in bronchospasm formation suggesting an active role of these bronchoconstrictors in asthma pathogenesis. Higher levels of 6-keto-PGF1 alpha are of a compensary nature in the pathogenesis of PGF2 alpha and TxB2 bronchoconstrictory action, and of damaging nature contributing to the formation of bronchial mucosa edema and bronchial gland hypersecretion.
ISSN:0023-2149