Interactions of radiation factors and smoking in the etiology of lung cancer in workers of atomic enterprises

It was shown on the basis of retrospective investigation of 500 workers at a nuclear enterprise (162 cases of lung cancer, 338 persons as matching control) that the interaction of external gamma-irradiation (> 2.0 Gy) and the body-burden of 239Pu (> 9.3 kBq) at lung cancer incidence in multipl...

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Bibliographic Details
Published in:	Radiat͡s︡ionnai͡a︡ biologii͡a︡, radioėkologii͡a Vol. 37; no. 6; p. 918
Main Authors:	Tokarskaia, Z B, Khokhriakov, V F, Okladnikova, N D, Beliaeva, Z D, Zhuntova, G V
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-11-1997
Subjects:	Body Burden Humans Lung Neoplasms - etiology Male Models, Theoretical Neoplasms, Radiation-Induced - etiology Nuclear Reactors Occupational Diseases Plutonium - adverse effects Radiation Dosage Retrospective Studies Smoking - adverse effects
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Summary:	It was shown on the basis of retrospective investigation of 500 workers at a nuclear enterprise (162 cases of lung cancer, 338 persons as matching control) that the interaction of external gamma-irradiation (> 2.0 Gy) and the body-burden of 239Pu (> 9.3 kBq) at lung cancer incidence in multiplicative. Combined influence of smoking and radiation factors was found dependent on smoking index (SI): it changed from additive up to multiplicative and than to antagonistic with the increase of the smoking effect. The received results could be explained on the basis of a two-mutation model of radiation carcinogenesis.
ISSN:	0869-8031