The immunogenicity of a cultured inactivated hepatitis A vaccine

A trial of inactivated hepatitis A viral vaccine of heteroploid cell culture origin is described. The vaccine preparation was tested in guinea pigs and tamarins. The animals were immunized intramuscularly four or three times, respectively. The efficacy was judged by induction of anti-HAV antibody pe...

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Bibliographic Details
Published in:	Voprosy virusologiĭ Vol. 36; no. 3; p. 206
Main Authors:	Kusov, Iu Iu, El'bert, L B, Kazachkov, Iu A, Val'iano, N M, Nel'ga, I V, Grishina, G K, Krutianskaia, G L, Lisitsyna, E A, Poleshchuk, V F, Sobol', A V
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-05-1991
Subjects:	Animals Antibodies, Viral - blood Drug Evaluation, Preclinical Guinea Pigs Hepatitis A - prevention & control Hepatovirus - immunology Immunization Immunoenzyme Techniques Immunoglobulin M - analysis Isocitrate Dehydrogenase - blood Male Saguinus Time Factors Vaccines, Inactivated - immunology Viral Hepatitis Vaccines - immunology
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Summary:	A trial of inactivated hepatitis A viral vaccine of heteroploid cell culture origin is described. The vaccine preparation was tested in guinea pigs and tamarins. The animals were immunized intramuscularly four or three times, respectively. The efficacy was judged by induction of anti-HAV antibody persisting for at least 12 months in guinea pigs, and development of immunity to subsequent virus challenge (monkeys only). The challenge dose of HAV was unable to produce any signs of HAV infection in the vaccinated tamarins, although the booster effect was observed in some animals. The study demonstrated that the tested batches of the vaccine were highly immunogenic.
ISSN:	0507-4088