The indices of the thrombocyte serotonin system and of the nerve growth factor system in children with hereditary disorders of neuropsychic development

Indices of both platelet serotoninergic system and the system of nerve growth factor (NGF) were examined in children with neurofibromatosis (15 patients), polygenic oligophrenia (24 patients) and Rett's syndrome (14 ones). There was an increase of both the level of blood serum autoantibodies (a...

Full description

Saved in:

Bibliographic Details
Published in:	Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova Vol. 98; no. 3; p. 27
Main Authors:	Brusov, O S, Zlobina, G P, Nikolaeva, E A, Ulas, V Iu, Faktor, M I, Pavlova, O A, Danilovskaia, E V, Kliushnik, T P, Kazantseva, L Z
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 1998
Subjects:	Adolescent Autoantibodies - blood Autoimmune Diseases - blood Blood Platelets - metabolism Child Child, Preschool Female Humans Intellectual Disability - blood Male Nerve Growth Factors - blood Nerve Growth Factors - immunology Neurofibromatosis 1 - blood Receptors, Nerve Growth Factor - blood Rett Syndrome - blood Serotonin - blood Tritium
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Indices of both platelet serotoninergic system and the system of nerve growth factor (NGF) were examined in children with neurofibromatosis (15 patients), polygenic oligophrenia (24 patients) and Rett's syndrome (14 ones). There was an increase of both the level of blood serum autoantibodies (aAB) to NGF and the value of specific binding of 3H-imipramine (Bmax) in platelets of patients with oligophrenia. For this group of patients a significant negative correlation exists between the rate of platelet uptake of serotonin (Vmax value) and the degree of mental retardation (r = -0.425, p < 0.03). Decrease of both Vmax and activity of platelet NGF receptors was revealed in patients with neurofibromatosis. In such patients there was positive correlation between sensitivity of platelet NGF receptors to NGF (during their stimulation by test dose of purified NGF) and the degree of mental retardation (r = 0.697, p < 0.04). In patients with Rett's syndrome a significant increase of activity of platelet NGF receptors to NGF was observed. The conclusion was made on the existence of some general mechanism of intellectual defect development. Autoimmune processes considered to be such mechanism.
ISSN:	1997-7298