Mechanism of the effect of phytohemagglutinin as a stimulator of wound healing

Phytohemagglutinin (PHA) produced by Difco, USA, (3.3 microgram per 1 mg of unguentum base) was tested as a stimulator of the healing of suppurative skin-muscle wounds 4 cm2 in area in 70 rabbits divided into 3 groups according to reaction to the intracutaneous test with PHA. Enhanced wound healing...

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Bibliographic Details
Published in:	Arkhiv patologii Vol. 42; no. 5; p. 26
Main Authors:	Bol'shakov, I N, Poberiĭ, I A, Lindner, D P, Zubkov, B A, Panasiuk, A V
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 1980
Subjects:	Animals Female Fibroblasts - pathology Follow-Up Studies Leukocytes - pathology Macrophages - pathology Male Muscles - injuries Muscles - pathology Phytohemagglutinins - pharmacology Rabbits Skin - injuries Skin - pathology Wound Healing
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Summary:	Phytohemagglutinin (PHA) produced by Difco, USA, (3.3 microgram per 1 mg of unguentum base) was tested as a stimulator of the healing of suppurative skin-muscle wounds 4 cm2 in area in 70 rabbits divided into 3 groups according to reaction to the intracutaneous test with PHA. Enhanced wound healing was observed only in poorly reacting rabbits (20.7 against 31.1 days in control). A considerable increase in the number of activated lymphocytes and cells of monocyte-macrophage group in the wound exudate, increased phagocytosis as well as more rapid and intensive development of proliferative processes were also established. The stimulation mechanism includes the direct PHA effect on inflammation cells and epithelium and a complex chain of both direct and mediated cellular interactions.
ISSN:	0004-1955