Use of proteolytic enzyme inhibitors for stabilizing medicinal substances during storage

Use of proteolytic enzyme inhibitors for stabilizing medicinal substances during storage

The possibility of stabilizing medicinal preparations of protein nature using the inhibitor of proteolytic enzymes, contrical (Trasilol) has been studied. On long storage, free ammonia and products of protein fragmentation accumulated in protein preparations, and the degree of amidation was reduced....

Full description

Saved in:
Bibliographic Details
Published in:Prikladnaja biohimija i mikrobiologija Vol. 30; no. 4-5; p. 709
Main Authors: Shepotinovskaia, I V, Umanskaia, N Ia, Pushkina, N V
Format: Journal Article
Language:Russian
Published: Russia (Federation) 01-07-1994
Subjects:
Aprotinin - pharmacology
Drug Stability
Drug Storage
Humans
Hydrolysis
Immunoglobulins - pharmacology
Online Access:Get more information
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The possibility of stabilizing medicinal preparations of protein nature using the inhibitor of proteolytic enzymes, contrical (Trasilol) has been studied. On long storage, free ammonia and products of protein fragmentation accumulated in protein preparations, and the degree of amidation was reduced. This led to the decrease in biological activity of immunoglobulins and insulin. Contrical produced a stabilizing effect irrespective of the nature of protein, and because of this may find an application in pharmacy.
ISSN:0555-1099