Status of the prostacyclin-thromboxane balance in patients with cerebrovascular disorders and the effect of the treatment with nifedipine

It is shown that in patients with cerebral circulatory disorders, the prostacyclin -thromboxane balance is replaced toward the latter one. As a result of nifedipine administration part of the test subjects demonstrate a rise of the content of prostacyclin and a decline of the concentration of thromb...

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Bibliographic Details
Published in:	Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952) Vol. 91; no. 7; p. 63
Main Authors:	Akopov, S E, Grigorian, G S, Kazarian, A V, Mkhitarian, G S, Tunian, Iu S, Gabrielian, E S
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 1991
Subjects:	6-Ketoprostaglandin F1 alpha - antagonists & inhibitors 6-Ketoprostaglandin F1 alpha - blood Acute Disease Aged Cerebral Infarction - drug therapy Cerebral Infarction - physiopathology Cerebrovascular Circulation - drug effects Cerebrovascular Circulation - physiology Epoprostenol - blood Humans Intracranial Arteriosclerosis - drug therapy Intracranial Arteriosclerosis - physiopathology Middle Aged Nifedipine - therapeutic use Thromboxane A2 - blood
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Summary:	It is shown that in patients with cerebral circulatory disorders, the prostacyclin -thromboxane balance is replaced toward the latter one. As a result of nifedipine administration part of the test subjects demonstrate a rise of the content of prostacyclin and a decline of the concentration of thromboxane. This effect of nifedipine is ascertained to be in a good agreement with its action on blood inflow to the brain and platelet aggregation. It is concluded that the efficacy of nifedipine can be raised if it is combined with the drugs that enhance the synthesis of prostacyclins in the body.
ISSN:	0044-4588