The endocrine pancreas in pluriglandular neoplasia type I. A report of two cases and review of the literature

The changes of the endocrine pancreas in two cases of pluriglandular neoplasia type I were studied. A 15 year-old girl showed an amyloid containing ductuloinsular B cell adenoma, microadenomas and nesidioblastic processes. The simultaneous presence of hyperprolactinemia and nephrolithiasis indicates...

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Bibliographic Details
Published in:	Zentralblatt fur allgemeine Pathologie u. pathologische Anatomie Vol. 127; no. 5-6; p. 375
Main Authors:	Kunz, J, Amendt, P, Hahn von Dorsche, H, Gerl, H, Knappe, E, Lorenz, D
Format:	Journal Article
Language:	German
Published:	Germany 1983
Subjects:	Adolescent Adult Female Humans Insulinoma - pathology Islets of Langerhans - pathology Kidney Calculi - pathology Multiple Endocrine Neoplasia - pathology Pancreatic Neoplasms - pathology Prolactin - blood
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Summary:	The changes of the endocrine pancreas in two cases of pluriglandular neoplasia type I were studied. A 15 year-old girl showed an amyloid containing ductuloinsular B cell adenoma, microadenomas and nesidioblastic processes. The simultaneous presence of hyperprolactinemia and nephrolithiasis indicates the existence of the endocrine polyadenomatosis. A 33 year-old woman had four amyloid containing B cell adenomas with ductular proliferation, a main cell adenoma of the parathyroid and a prolactinoma of the adenohypophysis. Solitary or multiple ductuloinsular adenomas, amyloid of the endocrine type and nesidioblastic activity are not specific features of the endocrine pancreas in pluriglandular adenomatosis. Similar structures can be found in isolated islet cell tumors or in nesidioblastosis. Ductuloinsular proliferations can also be observed in chronic pancreatitis.
ISSN:	0044-4030