Ethyl 2-([5,6-dihydro-7-(1H-imidazol-1-yl)-2-naphthalenyl]oxy)- 2-methylpropanoate as a new potent oxyisobutyrate hypolipidaemic with unusual features

Some compounds containing the N-imidazolyl and the ethyl oxy-isobutyrate groups linked to a naphthalene ring structure and some related analogues were synthesized and tested for hypolipidaemic activity. Ethyl 2-([5,6- dihydro-7-(1H-imidazol-1-yl)-2-naphthalenyl]oxy)- 2-methylpropanoate (V) proved to...

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Bibliographic Details
Published in:	Il Farmaco; edizione scientifica Vol. 42; no. 3; p. 205
Main Authors:	Cozzi, P, Branzoli, U, Carganico, G, Chiari, A, Lovisolo, P P, Severino, D
Format:	Journal Article
Language:	English
Published:	Italy 01-03-1987
Subjects:	Animals Bezafibrate - pharmacology Chemical Phenomena Chemistry Cholesterol - biosynthesis Cholesterol - blood Clofibrate - pharmacology Diet Hypercholesterolemia - drug therapy Hypolipidemic Agents - chemical synthesis Hypolipidemic Agents - pharmacology Imidazoles - chemical synthesis Imidazoles - pharmacology Lipoproteins, LDL - blood Male Naphthalenes - chemical synthesis Naphthalenes - pharmacology Rats
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Summary:	Some compounds containing the N-imidazolyl and the ethyl oxy-isobutyrate groups linked to a naphthalene ring structure and some related analogues were synthesized and tested for hypolipidaemic activity. Ethyl 2-([5,6- dihydro-7-(1H-imidazol-1-yl)-2-naphthalenyl]oxy)- 2-methylpropanoate (V) proved to be a strong hypolipidaemic agent, several times more potent than clofibrate. Structural requirements for activity and differences from clofibrate analogues are discussed.
ISSN:	0430-0920