Antigenic composition of serum proteins of the Inv system in normal conditions and in patients with hematologic diseases among the Armenian population

• Published in: Gematologiia i transfuziologiia Vol. 37; no. 2; p. 24
• Main Authors: Nersisian, V M, Musaelian, N O, Martirosian, I G
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 01-02-1992
• Subjects: Adolescent; Adult; Aged; Antigens - genetics; Antigens - immunology; Armenia - epidemiology; Blood Proteins - analysis; Epitopes - genetics; Epitopes - immunology; gamma-Globulins - genetics; gamma-Globulins - immunology; Genes, Immunoglobulin - genetics; Genes, Immunoglobulin - immunology; Hematologic Diseases - epidemiology; Hematologic Diseases - genetics; Hematologic Diseases - immunology; Humans; Immunoglobulin Light Chains - genetics; Immunoglobulin Light Chains - immunology; Middle Aged; Reference Values; Armenia
• ISSN: 0234-5730

Inv (1) antigen distribution was studied in 568 normal subjects and in 354 hematological patients in the Armenian population. Inv (1) antigen was detected in 16.7% of the normal Armenians studied. The incidence rate of Inv (1) factor does not depend on the distribution of phenotypes of ABO system, rhesus factor (D), and the sex of the subjects investigated. Inv (1) antigen incidence rate in patients with acute leukemia, chronic lymphocytic leukemia, iron deficiency anemia, lymphogranulomatosis, idiopathic thrombocytopenic purpura, autoimmune hemolytic anemia was similar to that in the control, and only patients with chronic myeloid leukemia had significantly decreased levels of Inv (1) antigen: 6.8% as compared to 16.7% in the population.