The epidemiology of spondyloarthropathies among the native inhabitants of Chukotka. 2. The prevalence of HLA-B27 in the population and among spondyloarthropathy patients

• Published in: Terapevtic̆eskii arhiv Vol. 66; no. 5; p. 41
• Main Authors: Benevolenskaia, L I, Erdes, Sh, Krylov, M Iu, Chekalina, N A
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 1994
• Subjects: Arctic Regions - epidemiology; Arthritis, Juvenile - ethnology; Arthritis, Juvenile - immunology; Arthritis, Reactive - ethnology; Arthritis, Reactive - immunology; Continental Population Groups; Cross-Sectional Studies; Female; HLA-B27 Antigen - blood; Humans; Incidence; Inuits - statistics & numerical data; Male; Oceanic Ancestry Group - statistics & numerical data; Prevalence; Siberia - epidemiology; Spinal Diseases - ethnology; Spinal Diseases - immunology; Spondylitis, Ankylosing - ethnology; Spondylitis, Ankylosing - immunology; Arctic Regions; Siberia
• ISSN: 0040-3660

To establish the incidence of HLA-B27 among the indigenous population of Chukot Peninsula, a one-stage cross-sectional study was made of all the natives of the two settlements of eastern Chukot Peninsula (Sireniki and Novo-Chaplino). At the moment of examination altogether 640 natives lived in both settlements. Of these, 464 persons (72.5%) could be examined clinically; HLA typing could be performed in 439 persons (68.6%). Among the 439 natives examined, antigen B27 was identified in 141 cases (32.1%). Among Eskimos, the number of HLA-B27-positive individuals amounted to 39.7%, among Chukchi to 18.9% (p = 0.0005). Half-breeds occupied an intermediate position between the two groups. The frequency of NLA-B27-positive cases was 29.7% among them. 7 patients were diagnosed to have diseases belonging to the group of spondyloarthropathies. 2 persons presented with ankylosing spondyloarthritis, 2 with Reiter's syndrome, 2 with undifferentiated spondyloarthropathies and 1 with juvenile chronic arthritis. All the patients with ankylosing spondyloarthritis and Reiter's syndrome appeared HLA-B27-positive.