The hormonal regulation of mRNA Na,K-ATPase expression in rat kidneys in postnatal ontogeny

A study was made of effects of aldosterone, aldosterone+dexamethasone, and aldosterone+spironolactone on Na,K-ATPase mRNA expression in renal cortex of adult and 10 day old rats, when kidney is not sensitive to the hormone injection. It is shown that hormonal induction of synthesis of Na,K-pump mRNA...

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Bibliographic Details
Published in:	T͡S︡itologii͡a Vol. 33; no. 11; p. 18
Main Authors:	Logvinenko, N S, Khlebodarova, T M, Solenov, E I, Ivanova, L N, Broude, N E, Monastyrskaia, G S
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 1991
Subjects:	Adrenalectomy Aging - drug effects Aging - physiology Aldosterone - pharmacology Animals Dexamethasone - pharmacology Enzyme Induction - drug effects Gene Expression Regulation, Enzymologic - drug effects Gene Expression Regulation, Enzymologic - physiology Kidney Cortex - enzymology Kidney Cortex - growth & development Male Rats Rats, Inbred Strains RNA, Messenger - biosynthesis RNA, Messenger - drug effects RNA, Messenger - genetics Sodium-Potassium-Exchanging ATPase - biosynthesis Sodium-Potassium-Exchanging ATPase - drug effects Sodium-Potassium-Exchanging ATPase - genetics Spironolactone - pharmacology
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Summary:	A study was made of effects of aldosterone, aldosterone+dexamethasone, and aldosterone+spironolactone on Na,K-ATPase mRNA expression in renal cortex of adult and 10 day old rats, when kidney is not sensitive to the hormone injection. It is shown that hormonal induction of synthesis of Na,K-pump mRNA occurs in the early postnatal period apart from mineral corticoid receptors. It seems probable that aldosterone exerts its action in 10 day old rats by interaction with glucocorticoid receptors inducing synthesis of different amounts of alpha- and beta-subunits of Na,K-ATPase.
ISSN:	0041-3771