Effect of stress and the adaptogen cucurbitacin R diglycoside on arachidonic acid metabolism

Rat leukocytic lipoxygenase activity is decreased in stress. The production of 12-hydroxy-5z, 8z, 10E-heptadecatrienic acid (12-HHT) (the product of cyclooxygenase metabolism of arachidonic acid-AA) is increased. Cucurbitacin R diglucoside (CRD), an adaptogen, raising working capacity and corticoste...

Full description

Saved in:

Bibliographic Details
Published in:	Problemy ėndokrinologii Vol. 35; no. 1; p. 58
Main Authors:	Panosian, A G, Dadaian, M A, Gevorkian, G A
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-01-1989
Subjects:	Animals Arachidonic Acids - metabolism Enzyme Activation Leukotrienes - biosynthesis Lipoxygenase - metabolism Male Neutrophils - metabolism Prostaglandin-Endoperoxide Synthases - metabolism Rats Restraint, Physical Stress, Physiological - metabolism Triterpenes - pharmacology
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Rat leukocytic lipoxygenase activity is decreased in stress. The production of 12-hydroxy-5z, 8z, 10E-heptadecatrienic acid (12-HHT) (the product of cyclooxygenase metabolism of arachidonic acid-AA) is increased. Cucurbitacin R diglucoside (CRD), an adaptogen, raising working capacity and corticosteroid secretion, produces a similar effect on leukocytes. Preliminary injection of CRD to animals prevents changes caused by stress, which indicates a CRD adaptogenic effect on the body.
ISSN:	0375-9660