Substance P--new aspect to its modulatory function

The paper deals with a modulatory function of Substance P (SP) (Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-MetNH2) with bearing on nociperception, behaviour, and norepinephrine uptake. The effect of SP on both nociperception and behaviour was found to depend on the original condition of the individuals...

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Bibliographic Details
Published in:	Acta biologica et medica Germanica Vol. 39; no. 4; p. 469
Main Authors:	Oehme, P, Hecht, K, Piesche, L, Hilse, H, Poppei, M, Morgenstern, E, Göres, E
Format:	Journal Article
Language:	English
Published:	Germany 1980
Subjects:	Acoustic Stimulation Animals Avoidance Learning - drug effects Blood Pressure - drug effects Conditioning (Psychology) Female Heart Rate - drug effects Hypothalamus - drug effects Hypothalamus - metabolism Nociceptors - drug effects Norepinephrine - metabolism Rats Reaction Time - drug effects Respiration - drug effects Substance P - pharmacology
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Summary:	The paper deals with a modulatory function of Substance P (SP) (Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-MetNH2) with bearing on nociperception, behaviour, and norepinephrine uptake. The effect of SP on both nociperception and behaviour was found to depend on the original condition of the individuals. The individual response time of mice to thermic stimuli becomes standardized by Substance P in the hot-plate test. Disorders in acquisition of avoidance reactions caused by noiseborne stress were found to be fully normalized by SP, like certain vegetative parameters, such as blood pressure, heart rate, and respiratory rate. SP was found to inhibit or stimulate norepinephrine uptake of hypothalamus preparations depending on the experimental conditions. It is recommended to name peptides of the above type of action as "regulatory peptides" (regulides).
ISSN:	0001-5318