Evaluation of the capacity of the thymus to accumulate testosterone and of the nature of its interaction with the thymocytes

It was found out that thymus accumulated 3H-testosterone from blood at the same degree as liver, prostate and skeletal muscle. However, hormone was quickly eliminated from the thymus and prostate accumulated it. Thymocytes bound about 5% of testosterone accumulated by the organ. The dependence of bi...

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Bibliographic Details
Published in:	Biulleten' eksperimental'noi biologii i meditsiny Vol. 106; no. 11; p. 611
Main Authors:	Chermnykh, N S, Ukhina, T V, Andreev, Iu A
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-11-1988
Subjects:	Animals Dose-Response Relationship, Drug Male Orchiectomy Rats Testosterone - metabolism Testosterone - pharmacology Thymus Gland - cytology Thymus Gland - drug effects Thymus Gland - metabolism Time Factors Tissue Distribution Tritium
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Summary:	It was found out that thymus accumulated 3H-testosterone from blood at the same degree as liver, prostate and skeletal muscle. However, hormone was quickly eliminated from the thymus and prostate accumulated it. Thymocytes bound about 5% of testosterone accumulated by the organ. The dependence of binding of 3H-testosterone by thymocytes in vitro and the absence of competition between labelled and unlabelled forms of hormone were revealed. The results obtained make it possible to conclude that thymocytes lack the systems of specific binding of androgen.
ISSN:	0365-9615