The effects of a cardioactive hypothalamic neurohormone on the isolated rat heart

On the isolated perfused by Langendorf at heart the cardioactive hypothalamic neurohormone NG3a (2 x 10(-5) g/ml) significantly decreased the coronary flow rate; the effect persisted during 5-10 min, after that the second phase appeared which was expressed by the increase of coronary flow rate. The...

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Bibliographic Details
Published in:	Nauchnye doklady vysshei shkoly. Biologicheskie nauki no. 1; p. 115
Main Authors:	Srapionian, R M, Karapetian, R O, Galoian, A A, Vinogradova, T M, Sokolova, N A
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 1993
Subjects:	Animals Coronary Circulation - drug effects Electrocardiography - drug effects Heart - drug effects Heart - physiology Heart Rate - drug effects Hypothalamic Hormones - pharmacology In Vitro Techniques Male Perfusion - methods Rats
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Summary:	On the isolated perfused by Langendorf at heart the cardioactive hypothalamic neurohormone NG3a (2 x 10(-5) g/ml) significantly decreased the coronary flow rate; the effect persisted during 5-10 min, after that the second phase appeared which was expressed by the increase of coronary flow rate. The maximum effect was 122% compared with control. The second phase appeared in 30-45 min after infusion of NG3a. NG3a did not influence the heart rate, but sometimes (7.3% cases) during the maximum increase of coronary flow the bradyarrhythmia was registered. It has been concluded that NG3a influences directly the coronary vessels.
ISSN:	0470-4606