Polymer-drug complexes in the treatment of extensive ovarian cancer

The paper presents the results of intracavitary chemotherapy with deposited cytostatics of advanced ovarian cancer as well experimental, morphological, biochemical and pharmacological data. Intraabdominal introduction of microspheres filled with cyclophosphamide, 5-fluorouracil, doxorubicin can be a...

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Bibliographic Details
Published in:	Sovetskaia meditsina no. 11; p. 27
Main Authors:	Novikova, E G, Borisov, V I, Dmitriev, D G, Zel'vin, B M, Karseladze, A I, Shchitkov, K G, Li, A D
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 1991
Subjects:	Adult Cellulose - analogs & derivatives Cyclophosphamide - administration & dosage Cystadenocarcinoma - drug therapy Doxorubicin - administration & dosage Evaluation Studies as Topic Female Fluorouracil - administration & dosage Humans Microspheres Middle Aged Ovarian Neoplasms - drug therapy
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Summary:	The paper presents the results of intracavitary chemotherapy with deposited cytostatics of advanced ovarian cancer as well experimental, morphological, biochemical and pharmacological data. Intraabdominal introduction of microspheres filled with cyclophosphamide, 5-fluorouracil, doxorubicin can be a variant of drug therapy in multimodality treatment of ovarian cancer. Combination of intracavitary chemotherapy with a systemic one has the advantage of local and regional effect which is not inhibited by mediated action of the deposited cytostatics via the systemic blood flow. The method is indicated in residual tumor dissemination after cytoreductive surgery and ovarian cancer with ascites.
ISSN:	0038-5077