Neurospecific cardioactive protein-hormone complexes in experimental myocardial infarct in rats

• Published in: Uspekhi fiziologicheskikh nauk Vol. 27; no. 3; p. 78
• Main Author: Srapionian, R M
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 01-07-1996
• Subjects: Animals; Brain - metabolism; Brain Chemistry; Disease Models, Animal; Hypothalamic Hormones - analysis; Hypothalamic Hormones - metabolism; Male; Molecular Weight; Myocardial Infarction - metabolism; Myocardial Ischemia - metabolism; Myocardium - chemistry; Myocardium - metabolism; Radioimmunoassay - methods; Radioimmunoassay - statistics & numerical data; Rats; Viscera - chemistry; Viscera - metabolism
• ISSN: 0301-1798

The method of radioimmune analysis was used to explore distribution of the cardioactive protein-hormone complexes extracted from oxen hypothalamus in rats with simulated myocardial infarction. The above cardial pathology is associated with devastation of these complexes in cerebrum, in particular, in the cortex of big hemispheres, hypothalamus, and cerebellum (12 to 130 times reduction). Simultaneously, the amount of immune-reactive protein-hormone complexes in some visceral organs and in blood was observed to intensively increase. The observations of 6-340 times of the above complexes suggest that they reach a new homeostatic level of concentration in the peripheral organs and tissue which should increase blood circulation in tissue, and in particular, in the myocardium. High biological role of the above complexes in regulation of the cardial and vascular functions and their anomalous multiplication in cardium enables us to suggest their possible participation of the complexes in reparation of a necrotic zone in myocardium.