Prevention of peritoneal adhesion formation with a combination of carboxymethyl-cellulose and papain: experimental study

• Published in: Arquivos de gastroenterologia Vol. 28; no. 2; p. 63
• Main Authors: Parra, O M, Saad, W A, Ferri, S, Peduto, L, Ferraz Neto, J B, Dal Colletto, G M
• Format: Journal Article
• Language: Portuguese
• Published: Brazil 01-04-1991
• Subjects: Animals; Carboxymethylcellulose Sodium - therapeutic use; Drug Combinations; Female; Papain - therapeutic use; Peritoneum; Rats; Rats, Inbred Strains; Tissue Adhesions - prevention & control
• ISSN: 0004-2803

The inhibitory action of sodium carboxymethylcellulose (CMC) and papain (PP) in peritoneal adhesions formation, were studied in Wistar rats. After ether anesthesia and a midline laparotomy incision, the right parietal peritoneum was pinched with a fine hemostat and the pinched peritoneal fold was then ligated. This maneuver was repeated thrice creating four point as if they were little "polyps" with a standardized size. Before closing the incision, it was deposited on the four points of each animal the following substances: group A--saline solution; group B--CMC 2%; group C--PP 0.4% in distilled water; group D--CMC 2% + PP 0.2%; group E--CMC 2% + PP 0.4%. After ten days, the rats were sacrificed and classified according to the number of "points" that showed adhesions with the abdominal structures. There was a statistically significant decrease in the incidence of adhesions only in the group E (CMC + PP 0.4%).