Distribution of neurospecific cardioactive protein-hormone complex in the rat body during experimental myocardial ischemia

• Published in: Biulleten' eksperimental'noi biologii i meditsiny Vol. 109; no. 2; p. 147
• Main Authors: Gabrielian, S K, Srapionian, R M, Abelian, Zh G, Galoian, A A
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 01-02-1990
• Subjects: Animals; Brain - metabolism; Cerebral Cortex - metabolism; Coronary Disease - metabolism; Glycoproteins - metabolism; Hypothalamic Hormones - metabolism; Male; Nerve Tissue Proteins - metabolism; Radioimmunoassay; Rats; Spleen - metabolism; Tissue Distribution
• ISSN: 0365-9615

For more than 25 years the chemistry and the function of the protein-hormonal complexes (produced by magnocellular nuclei of human and same animals) have been studied. The methods of radioimmunological analyses (RIA) for the detection of new neuropecific cardioactive protein-hormone "K" (RHK) in rat organism with myocardial ischemia has been developed. Concentration of PHK in various regions of the brain by RIA a four days after the occlusion of the carotid artery has a sharp decrease. Particularly concentration of PHK decreases 100-fold in the cerebral cortex. At the same time the level of PHK content in the blood increased from 13 +/- 0.85 to 630 +/- 3.9 ng/ml. The maximum concentration of PHK shows a sharp rise in the spleen 200-fold of their original level. This distribution pattern implies that PHK may be of importance for peripheral tissues and to the scarring in heart neurosis zone.