Effect of extracorporeal sorption on the content of free intracellular calcium of the leukocytes in atopic bronchial asthma

Antigen-IgE-antibody interaction on the cell surface in an allergic reaction increases methylation of phospholipids of a cell membrane making it permeable for Ca2+ ions. Therefore of interest is a study of free intracellular Ca2+ concentration from a view-point of development of atopic bronchial ast...

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Bibliographic Details
Published in:	Terapevtic̆eskii arhiv Vol. 60; no. 12; p. 58
Main Authors:	Efendieva, I S, Rudchenko, S A, Kormosh, T, Khurkhulu, Z S, Grigorian, G Iu
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 1988
Subjects:	Adult Antigen-Antibody Complex - therapeutic use Asthma - blood Asthma - therapy Calcium - blood Charcoal Female Hemoperfusion - methods Humans Immunosorbents - therapeutic use Leukocytes - metabolism Male Middle Aged Rhinitis, Allergic, Perennial - blood Rhinitis, Allergic, Perennial - therapy Sinusitis - blood Sinusitis - therapy
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Summary:	Antigen-IgE-antibody interaction on the cell surface in an allergic reaction increases methylation of phospholipids of a cell membrane making it permeable for Ca2+ ions. Therefore of interest is a study of free intracellular Ca2+ concentration from a view-point of development of atopic bronchial asthma and the use of extracorporal methods of its therapy permitting the elimination of IgE-antibodies from the blood flow. The level of intracellular Ca2+ in the leukocytes of patients with atopic bronchial asthma was studied. It has been shown that 1. the fraction of leukocytes with a higher level of intracellular Ca2+ in patients with atopic bronchial asthma was increased as compared to healthy donors; 2. extracorporal sorption results in a decrease in the number of leukocytes with high Ca concentration.
ISSN:	0040-3660