Peroperative administration of 5-fluorouracil during trabeculectomy in complicated glaucoma in children

• Published in: Česká a slovenská oftalmologie Vol. 54; no. 2; p. 86
• Main Authors: Filous, A, Burdová, M
• Format: Journal Article
• Language: Czech
• Published: Czech Republic 01-04-1998
• Subjects: Adolescent; Antimetabolites - administration & dosage; Child; Child, Preschool; Female; Fluorouracil - administration & dosage; Glaucoma - physiopathology; Glaucoma - surgery; Humans; Intraocular Pressure; Male; Trabeculectomy
• ISSN: 1211-9059

The authors evaluate the results of preoperative 5-minute administration of 5-fluorouracil (5-FU), 50 mg/ml, during trabeculectomy on 11 high risk eyes of children with primary and secondary glaucoma. The mean age of the patients was 7.3 years, the average follow-up period 8.9 months (6-12 months). The intraocular pressure (i.o.p) of 11 eyes before surgery varied between 23 and 46 torr, average 31.5 torr, after treatment it was 13 to 28 torr, average 18.4 torr. The mean drop of IOP was 41.6%. In 7 eyes during the last assessment of IOP < 21 torr with a drop of more than 30%. The remaining 4 eyes have a was IOP between 25 and 28 torr with a reduction of 19-39%. Serious postoperative complications comprised four times marked hypotonia with a shallow anterior chamber, twice choroidal ablation and once macular oedema associated with transient deterioration of vision. In view of the limited therapeutic possibilities of high risk types of glaucoma in children postoperative administration of 5-FU is a promising alternative for the reduction of IOP.