Post-stress correlation of the functional activity of macrophages by tuftsin and its derivatives

The effect of 15 day programmed neurotization on the functional activity of the peritoneal macrophages has been studied. The NBT-test and the adhesion measurements were used. The experimental neurosis resulted in the decrease of the macrophage functional activity and in leukopenia. Tuftsin did not r...

Full description

Saved in:

Bibliographic Details
Published in:	Biulleten' eksperimental'noi biologii i meditsiny Vol. 108; no. 7; p. 64
Main Authors:	Bulatova, N R, Romanova, E A, Krinskaia, A V, Sarychev, E I, Val'dman, A V
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-07-1989
Subjects:	Adrenal Glands - anatomy & histology Adrenal Glands - immunology Adrenocorticotropic Hormone - blood Animals Macrophages - physiology Male Neurotic Disorders - etiology Neurotic Disorders - immunology Nitroblue Tetrazolium Organ Size Rats Stress, Physiological - blood Stress, Physiological - immunology Tuftsin - analogs & derivatives Tuftsin - pharmacology
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	The effect of 15 day programmed neurotization on the functional activity of the peritoneal macrophages has been studied. The NBT-test and the adhesion measurements were used. The experimental neurosis resulted in the decrease of the macrophage functional activity and in leukopenia. Tuftsin did not restore the stress induced depression of macrophage activity but led to additional rise of the adrenal glands weight and to pronounced granulocyte-monocytosis. Pentapeptide analog of tuftsin gave the additional inhibition of NBT-activity of the macrophage. Heptapeptide analog favoured the restoration of the macrophage activity after neurotization and stimulated lymphopoiesis.
ISSN:	0365-9615