Liver mitochondrial participation in the body adaptation reactions in a rat heart transplant

Alterations in coupling of respiration and phosphorylation as well as in energy-dependent transport of calcium in liver mitochondria of recipient were studied in dynamics of antigenic response to rat heart transplantation. As compared with the normal state the reactions studied varied in opposite di...

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Bibliographic Details
Published in:	Voprosy meditsinskoi khimii Vol. 27; no. 6; p. 755
Main Authors:	Saakian, I R, Karapetian, T D
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-11-1981
Subjects:	Adaptation, Physiological Animals Energy Metabolism Graft Rejection Heart Transplantation Mitochondria, Liver - metabolism Oxidative Phosphorylation Oxygen Consumption Rats Rats, Inbred Strains
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Summary:	Alterations in coupling of respiration and phosphorylation as well as in energy-dependent transport of calcium in liver mitochondria of recipient were studied in dynamics of antigenic response to rat heart transplantation. As compared with the normal state the reactions studied varied in opposite directions, towards activation (hyperergic step) within 1-4 days after the heart transplantation and to decrease in their activity (hyperergic step) within 6-10 days; the latter period was characterized by development of the state similar to pathological one. Increased in amount of endogenous succinic acid as well as in succinate dehydrogenase activity were apparently among the other factors responsible for activation of energy metabolism in the hyperergic state. The reactions of liver mitochondria studied were identified as unspecific adaptation of the recipient liver tissue, which might be used for diagnosis of early steps of rejection crisis.
ISSN:	0042-8809