The characteristics of the cerebral circulation in arterial hypertension

• Published in: Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova Vol. 77; no. 9; p. 67
• Main Authors: Gabrielian, E S, Akopov, S E, Grigorian, G S, Kazarian, A V
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 01-09-1991
• Subjects: Blood Flow Velocity - drug effects; Blood Flow Velocity - physiology; Carotid Arteries - drug effects; Carotid Arteries - physiopathology; Carotid Artery Diseases - drug therapy; Carotid Artery Diseases - physiopathology; Cerebrovascular Circulation - drug effects; Cerebrovascular Circulation - physiology; Humans; Hypertension - drug therapy; Hypertension - physiopathology; Intracranial Arteriosclerosis - drug therapy; Intracranial Arteriosclerosis - physiopathology; Middle Aged; Nifedipine - pharmacology; Nifedipine - therapeutic use; Vascular Resistance - drug effects; Vascular Resistance - physiology; Xenon Radioisotopes
• ISSN: 0015-329X

In arterial hypertension, cerebral blood flow (CBF) in patients with chronic cerebrovascular diseases is lower than in patients without hypertension. In stenosis of internal carotid arteries, hypertension leads to the disturbance of the response of resisting cerebral vessels compensating the decrease of perfusion pressure at the expense of vessel dilation. As compared with patients without hypertension, the difference between the values of regional CBF (rCBF) in various regions of the brain is more obvious with the appearance of alternate hypoemic and hyperemic regions. After nifedipine, both an increase and a decrease of hemispheric CBF is possible in these patients. In many of them such changes in CBF are combined with further increase of the difference between rCBF values in various parts of the brain with the formation of well marked zones with relative ischemia and hyperemia.