Floating rates of synchronized CHO fibroblasts following 60Co gamma irradiation

Monolayer cell colonies normally are pushing off single cells, which go into suspension. A dose-dependent increase of these cell detachments followed by readhesion and colony forming would influence the colony survival curve. Detached cells being in suspension can be verified by means of the colony...

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Bibliographic Details
Published in:	Strahlentherapie Vol. 151; no. 4; p. 366
Main Authors:	Töllner, D, Hagemann, G
Format:	Journal Article
Language:	German
Published:	Germany 01-04-1976
Subjects:	Animals Cell Adhesion - radiation effects Cell Division - radiation effects Cell Line Cobalt Radioisotopes Cricetinae Female Fibroblasts - radiation effects Ovary - cytology Radiation Dosage Radiation Effects Time Factors
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Summary:	Monolayer cell colonies normally are pushing off single cells, which go into suspension. A dose-dependent increase of these cell detachments followed by readhesion and colony forming would influence the colony survival curve. Detached cells being in suspension can be verified by means of the colony forming test after decantation and inoculation of the medium. The amount of colony forming cells in the late phase of synthesis does scarcely change following 300 rds of 60Co gamma irradiation. The diminution of cell adhesion expected as a result of radiation damage could not be observed.
ISSN:	0039-2073