The effect of the delta sleep peptide and serotonin on the neurons of the snail

The present paper describes the results concerning the influence of delta sleep-inducing peptide (DSIP) and serotonin (5-HT) on electrophysiological properties of the identified snail neurons. The experiments were performed on semi-intact preparations from Helix lucorum L. DSIP inhibited spontaneous...

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Bibliographic Details
Published in:	Zurnal vyss̆ej nervnoj dejatelnosti imeni I P Pavlova Vol. 44; no. 2; p. 342
Main Authors:	Karpenko, L D, Aroian, E V, Mendzheritskiĭ, A M, Filin, N N
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-03-1994
Subjects:	Animals Delta Sleep-Inducing Peptide - pharmacology Dose-Response Relationship, Drug Helix (Snails) - drug effects Helix (Snails) - physiology In Vitro Techniques Microelectrodes Neurons - drug effects Neurons - physiology Physical Stimulation Serotonin - pharmacology Synaptic Transmission - drug effects Synaptic Transmission - physiology
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Summary:	The present paper describes the results concerning the influence of delta sleep-inducing peptide (DSIP) and serotonin (5-HT) on electrophysiological properties of the identified snail neurons. The experiments were performed on semi-intact preparations from Helix lucorum L. DSIP inhibited spontaneously active neurons and reduced responses of silent cells to depolarizing currents and tactile stimuli. DSIP effects were dose-dependent. 5-HT excited neurons in question. DSIP and 5-HT had the mutually opposite effects on the identified neurons. The results suggest that DSIP can directly affect the snail neurons not via serotoninergic system. Hyperpolarization effect of DSIP can be due to the enhancement of Cl conduction or to the changes in adenylatcyclase system activity. Alternatively DSIP can influence the process of synaptic transmission.
ISSN:	0044-4677