Mechanisms, kinetics and specificity of the leukocyte adherence inhibition test in breast cancer

The simplified micromodification of the leukocyte adhesion inhibition (LAI) test has shown that the LAI tests both for lymphocytes and for leukocytes may be equally used as additional methods of diagnostics of the early stages of breast cancer. The detailed study of the kinetics and cellular mechani...

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Bibliographic Details
Published in:	Eksperimentalʹnaja onkologija Vol. 7; no. 6; p. 69
Main Authors:	Kharkevich, D D, Polevaia, E B, Derevnina, N A, Sablikova, Iu A, Savinov, A Iu
Format:	Journal Article
Language:	Russian
Published:	Ukraine 1985
Subjects:	Antigens - immunology B-Lymphocytes - immunology Breast Neoplasms - diagnosis Breast Neoplasms - immunology Dose-Response Relationship, Immunologic Evaluation Studies as Topic Female Humans Immunologic Techniques - instrumentation Kinetics Leukocyte Adherence Inhibition Test - instrumentation Leukocyte Adherence Inhibition Test - methods Serologic Tests - methods T-Lymphocytes - immunology Time Factors
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Summary:	The simplified micromodification of the leukocyte adhesion inhibition (LAI) test has shown that the LAI tests both for lymphocytes and for leukocytes may be equally used as additional methods of diagnostics of the early stages of breast cancer. The detailed study of the kinetics and cellular mechanisms of the method has shown that the LAI reaction belongs to the earliest reactions of T-cellular immunity and is mediated by T-cell lymphokine. The study of sensitivity and specificity of the method revealed that the suggested micromodification of the LAI test may be used in experimental and clinical research for the study of the subpopulation of T-cells-producers of the LAI factor as well as for monitoring of the T-cell immunity in the cancer patients during treatment.
ISSN:	0204-3564