Specific features of cardiovascular diseases in patients with mono- and polygenic types of dyslipoproteinemia

• Published in: Vestnik Rossiĭskoĭ akademii medits︠i︡nskih nauk no. 10; p. 56
• Main Authors: Ol'binskaia, L I, Zakharova, V L
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 1998
• Subjects: Arteriosclerosis - blood; Arteriosclerosis - complications; Cardiovascular Diseases - blood; Cardiovascular Diseases - complications; Female; Humans; Hyperlipoproteinemias - blood; Hyperlipoproteinemias - complications; Hyperlipoproteinemias - genetics; Lipoproteins - blood; Male; Middle Aged; Phenotype
• ISSN: 0869-6047

Atherosclerosis as a key factor of cardiovascular morbidity and mortality is one of the most pressing problem of modern medicine. Most phenotypic deviations of serum cholesterol levels are genetically predetermined and the influence of environmental factors is much less. The vast majority of hereditary dyslipoproteinemia are polygenic. Monogenic disorders are seen in a small proportion of patients with atherosclerosis. However, they only emphasizes the carriage of alleles of the genes that determine various aspects of lipid genesis, transport, and predisposition to atherosclerosis. Virtually all primary dyslipoproteinemias appear as atherogenic types and they represent a special form of atherosclerosis. This fact affects the specific features of cardiovascular diseases in patients with hereditary hyperlipidemias. In these patients coronary heart disease as the most common manifestation of atherosclerosis occurs just in infancy, it is malignant and progressive and unresponsive to treatment. Furthermore, there is a drastic increase in the likelihood of a menacing and fatal complication, such as sudden death. For therapeutical and preventive purposes, these all factors make it necessary to perform a comprehensive early diagnosis of hereditary dyslipoproteinemias by using clinical, genealogical and routine studies, followed by correction of the disorders detected.