Effect of adaptation to hypoxia on the antioxidant enzyme activity in the liver in animals that have undergone stress

It was shown in experiments on rats that emotional-painful stress resulted in a rapid increase in malonic dialdehyde (MDA) and in a decrease in the activity of superoxide dismutase (SOD) in liver. Adaptation to moderate intermittent hypoxia in altitude chamber did not affect MDA and increased hepati...

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Bibliographic Details
Published in:	Biulleten' eksperimental'noi biologii i meditsiny Vol. 106; no. 11; p. 528
Main Authors:	Tverdokhlib, V P, Konovalova, G G, Lankin, V Z, Meerson, F Z
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-11-1988
Subjects:	Adaptation, Physiological Animals Atmosphere Exposure Chambers Glutathione Peroxidase - metabolism Glutathione Transferase - metabolism Hypoxia - enzymology Lipid Peroxidation Liver - enzymology Male Malondialdehyde - metabolism Rats Rats, Inbred Strains Stress, Psychological - enzymology Superoxide Dismutase - metabolism Time Factors
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Summary:	It was shown in experiments on rats that emotional-painful stress resulted in a rapid increase in malonic dialdehyde (MDA) and in a decrease in the activity of superoxide dismutase (SOD) in liver. Adaptation to moderate intermittent hypoxia in altitude chamber did not affect MDA and increased hepatic SOD by 65%. Stress exposure caused no change in SOD and MDA, but abruptly reduced the fall of SOD in adapted animals. These data are in accordance with the well-known idea that adaptation to hypoxia prevents the activation of lipid peroxidation and the hepatic damage in stress.
ISSN:	0365-9615