Opiate activity of a bone marrow humoral factor which stimulates antibody production

The radioceptor method was used to demonstrate that humoral factor of the bone marrow, a stimulant of antibody production (SAP), contains substances that competitively remove 3H-morphine and 3H-met-enkephalin from opiate receptors of the rat brain, and 3H-met-enkephalin from specific binding sites o...

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Bibliographic Details
Published in:	Biulleten' eksperimental'noi biologii i meditsiny Vol. 95; no. 5; p. 46
Main Authors:	Petrov, R V, Vartanian, M E, Zozulia, A A, Patsakova, E, Kost, N V
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-05-1983
Subjects:	Animals Antibody Formation - drug effects Binding Sites Binding, Competitive Bone Marrow - physiology Brain - metabolism Enkephalin, Methionine - metabolism Female Lymphocytes - metabolism Morphine - metabolism Rats Rats, Inbred Strains Receptors, Opioid - metabolism
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Summary:	The radioceptor method was used to demonstrate that humoral factor of the bone marrow, a stimulant of antibody production (SAP), contains substances that competitively remove 3H-morphine and 3H-met-enkephalin from opiate receptors of the rat brain, and 3H-met-enkephalin from specific binding sites on human lymphocytes. Comparison of the magnitudes EC50 SAP obtained during the removal of labeled opiates allows a suggestion to be made that opiates contained by the preparation under study have a greater capability to interact with delta-type opiate receptors rather than with those of the mu-type.
ISSN:	0365-9615